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In each study following a 4 week single-blind placebo baseline period, patients were randomized, under double blind conditions, to divalproex sodium delayed-release tablets or placebo for a 12 week treatment phase, comprised of a 4 week dose titration period followed by an 8 week maintenance period.

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Divalproex sodium should be considered for women of childbearing potential only after the risks have been thoroughly discussed with the patient and weighed against the potential benefits of treatment.

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Licinio added there are few studies that looked at the drugs in realworld settings, which often means in combination with other drugs.

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Food and Drug Administration (FDA) approved valproic acid in 1978 for the treatment of seizure disorder and approved divalproex sodium, its enteric-coated counterpart, in 1986 for the same indication.

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Continue therapy in responsive patients as long as clinically necessary and tolerated but at lowest possible effective dosage; reassess need for continued therapy and optimal dosage periodically (e.

Lisa Ronan, a research associate in the department of psychiatry at the University of Cambridge in England.

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The main migraine preventive drugs studied in this category included divalproex and sodium valproate, gabapentin, lamotrigine, oxcarbazepine, and topiramate.

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First one, assuming you guys get the clinical hold lifted in the outlined timeframe, just wondering, are you at production scale that would allow you to dose every patient in the third cohort immediately or is that a rate limiting step to completion of enrollment.

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